By taking a closer
By taking a closer look to these intriguing ?bacteria eating? viral agents, medical scientists may soon find an efficient cure for various diseases that involve malignant behavior of otherwise harmless bacteria.
Concerning strep throat, medical scientists believe that a type of toxin-producing bacteriophage carries a toxin gene present in its genome to Group A hemolytic streptococcus bacteria, transforming this otherwise neutral organism into a threatening microbe. The process through which the bacteriophage transforms the neutral organism into a disease-causing microbe is known as lysogenic conversion. Inside the human body, this process is accelerated and facilitated by a factor in the saliva referred to as SPIF (soluble phage inducing factor). SPIF has been identified to mobilize the bacteriophage, which enters in lysogenic conversion with streptococcus bacteria, thus causing strep throat.
A series of experiments conducted on mice have revealed that virtually any bacterium carrying a toxin-encoded bacteriophage can transform non-toxigenic organisms inside the body into toxigenic infectious agents. According to the findings, non-infectious bacteria can become toxigenic by entering in contact with organisms carrying toxin-encoded bacteriophages. The studies suggest that the treatment of strep throat and various other infectious diseases that involve lysogenic conversion between bacteriophages and non-toxigenic bacteria should be aimed not only at controlling the causative microbe (in the case of strep throat ? Group A hemolytic streptococcus bacteria), but also the bacteriophages that facilitate the occurrence of the infection.
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